Prof. Dr. Robert Grass

Prof. Dr. Robert Grass

Lecturer at the Department of Chemistry and Applied Biosciences

ETH Zürich

Inst. f. Chemie- u. Bioing.wiss.

HCI E 111

Vladimir-Prelog-Weg 1-5/10

8093 Zürich

Switzerland

Enlarged view: RG

Robert Grass (1979, Austrian/Swiss) is Titulary Professor at the Functional Materials Laboratory at ETH Zurich. He studied Chemical Engineering at ETH with a stay at CASE Western Reserve University Cleveland in 2003 after which he pursued a PhD at ETH Zurich. 2021 he spent 6 months at the company Lonza AG to external page assist the manufacturing of vaccines.

Robert Grass is involved in several areas of teaching chemistry, involving courses for small children, high-school chemistry education, process control education of chemical engineers at ETH Zurich. His research encompasses nanomaterial science, surface chemistry and nucleic acid research and has resulted in over 145 research papers, 17 patents and 4 book chapters. Robert Grass is recipient of the external page 2021 European Inventor award.

Research Focus

His research started in the field of surface functionalized nanomaterials, which he commercialised via the ETH Spin-Off company external page TurboBeads GmbH in 2007. These products have been sold to more than 1000 different customers, are available via external page Sigma Aldrich, and have enabled novel commercial bioanalytical tools. The corresponding technology is also at the core of the ETH Spin-Off company external page hemotune AG, which focuses on the treatment of sepsis.

A second, and more recent part of Grass' work involves the encapsulation of DNA in nanoscopic glass particles, and the use of these particles in the tagging of materials, enabling the integration of a digital signatures into a wide range of products ranging from valuables, external page consumer goods and foodstuff. This technology is currently being commercialised via the ETH Spin-Off Company external page Haelixa GmbH by two of his former PhD students. The company allows raw material tracking throughout the supply chain.

Currently, Robert Grass' Team is working on using DNA as a digital information technology and using this technology for the long-term archiving of digital data as well as the usage of DNA as a technology to integrate digital production information into physical items. A new and growing area of interest of the group is in occupational hygiene and the development of technologies to measure and understand the spread of bacteria and viruses.

Project descriptions.

Public Science Outreach

Selected publications

Full publication list on external page Google Scholar:

  • A. M. Lüscher, J. Koch, W. J. Stark, R. N. Grass
    Silica-encapsulated DNA tracers for measruing aerosol distribution dynamics in real-world settings
    Indoor Air 32(1), e12945 (2022).
    external page Link
  • C. Ullrich, A. M. Lüscher, J. Koch, R. N. Grass, H. Sax
    Silica nanoparticles with encapsulated DNA (SPED) to trace the spread of pathogens in healthcare
    Antimicrobial Resistance & Infection Control 11 (1), 1-13 (2022). external page Link
  • L. C. Meiser, J. Koch, P. L. Antkowiak, W. J. Stark, R. Heckel, R. N. Grass
    DNA synthesis for true random number generation
    Nature Communications 11, 5869 (2020). external page Link
  • P. L. Antkowiak, J. Lietard, M. Z. Darestani, M. M. Somoza, W. J. Stark, R. Heckel, R. N. Grass
    Low Cost DNA data storage using photolithographic synthesis and advanced information reconstruction and error correction
    Nature Communications 11, 5345 (2020). external page Link
  • J. Koch, S. Gantenbein, K. Masania, W. J. Stark, Y, Erlich, R. N. Grass
    A DNA-of-things storage architecture to create materials with embedded memory
    Nature Biotechnology 38, 39-43 (2020). external page Link
  • L. C Meiser, P. L Antkowiak, J. Koch, W. D. Chen, A. X. Kohll, W. J. Stark, R. Heckel, R. N. Grass
    Reading and writing digital data in DNA
    Nature Protocols 15, 86-101 (2020). external page Link
  • R. N. Grass, R. Heckel, M. Puddu, D. Paunescu, W. J. Stark
    Robust Chemical Preservation of Digital Information on DNA in Silica with Error-Correcting Codes
    Angewandte Chemie Int. Ed. 54, 2552-2555 (2015). external page Link
  • R. N. Grass, E. K. Athanassiou, W. J. Stark
    Covalently functionalized cobalt nanoparticles as a platform for inexpensive magnetic separations in organic synthesis
    Angewandte Chemie Int. Ed. 46, 4909-4912 (2007). external page Link
  • R. N. Grass, S. Tsantilis, S. E. Pratsinis
    Design of high-temperature, gas-phase synthesis of hard or soft TiO2 agglomerates
    AIChE Journal 52, 1318-1325 (2006). external page Link
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