Anne Lüscher receives Swiss Aerosol Award 2022

The circulation of pathogens in the form of aerosols is an important route of transmission of diseases and respiratory infections in particular. However, the COVID-19 pandemic has once again shown that airborne virus distribution is extremely complex and that current understanding is insufficient to make accurate predictions about the transmission dynamics in practice. To improve this understanding, tracers - substances that behave similarly to aerosolized viruses in terms of size and properties - are essential. Anne Lüscher and her co-authors therefore developed a new tracing method to improve and simplify the study of indoor aerosol dynamics. In their award-winning work, they were able to show that silica particles with encapsulated DNA (SPEDs) can be deployed in aerosolized form, followed by recapturing and quantification at different positions. This is enabled by “DNA barcodes” enclosed in the particles: Short synthetic DNA sequences can be reliably detected by the PCR method with high accuracy and a sensitivity at the single-particle level. The silica matrix on the one hand protects the DNA and, on the other hand, can be produced size-specifically. In the published work, position-, ventilation- and time-dependent effects of indoor aerosol exposure could be demonstrated using SPEDs, enabling conclusions on the room architecture and air circulation. The proposed setup requires little technical infrastructure and is therefore mobile, making it particularly suitable for the investigation of real-life exposure scenarios in indoor settings, transportation scenarios and the environment (external page Link).